Association of serum homocysteine with posterior circulation intracranial aneurysms: an institutional cross-sectional cohort, systematic review and meta-analysis.
Jefferson Rosi, Pedro Ithallo Ferreira Leite, Joao Pedro Costa Cruz et al.
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In 30 seconds
This study evaluated the association of serum homocysteine (Hcy) levels with intracranial aneurysm (IA) rupture and location in a cohort of 342 patients. The cross-sectional analysis found no significant difference in Hcy levels between ruptured and unruptured IAs (11.4 vs 10.7 µmol/L; p = 0.414). However, elevated Hcy was independently associated with posterior circulation aneurysms (OR = 1.14, p = 0.011).
Key findings
- No significant difference in median Hcy levels between unruptured and ruptured IAs (11.4 vs 10.7 µmol/L; p = 0.414).
- Meta-analysis of 1,457 patients confirmed no association between Hcy levels and IA rupture (SMD = 0.30, p = 0.158).
- Elevated Hcy levels were independently associated with posterior circulation aneurysms (OR = 1.14, p = 0.011).
- Significant variance in median Hcy across aneurysm topographies was observed (p = 0.011).
Why it matters
Understanding the role of serum homocysteine in intracranial aneurysms could inform risk assessment and management strategies. The association with posterior circulation aneurysms may suggest a specific pathophysiological mechanism that warrants further investigation.