Endoscopic Ultrasound-Guided Franseen Fine-Needle Biopsy for Solid Pancreatic Lesions: A Systematic Review and Meta-Analysis.
Adnan Bhat, Muhammad Arham, Zahra Ali et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic performance of the Franseen fine-needle biopsy (FNB) for solid pancreatic lesions compared to other FNB designs. Involving 16 studies with 2,010 Franseen and 2,811 comparator cases, the Franseen needle demonstrated comparable sensitivity (91.3% vs. 94.0%) and superior diagnostic accuracy (RR 1.07) compared to newer-generation needles, while reducing low-cellularity samples and specimen bloodiness.
Key findings
- Franseen needle sensitivity was 91.3% compared to 94.0% for newer-generation needles.
- Diagnostic accuracy was higher with the Franseen needle (RR 1.07, 95% CI 1.01-1.14).
- Franseen needle had fewer low-cellularity samples (RR 0.56, 95% CI 0.45-0.69).
- Overall adverse event rate was slightly higher for the Franseen needle (RR 1.29, 95% CI 1.06-1.57).
Why it matters
Accurate tissue acquisition is crucial for managing solid pancreatic lesions. The Franseen needle's improved diagnostic accuracy and reduced low-cellularity samples may enhance clinical decision-making and patient outcomes in gastroenterology.