Effectiveness of Platelet Rich Plasma in Reducing Oronasal Fistula and Scar Width in Primary Cleft Lip and Palate Repair-A Systematic Review and Meta-Analysis.
Thiagasirpi Mani, Naveen Munusamy, Prema Anbarasu et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in reducing oronasal fistula and scar width in patients aged 6-24 months undergoing primary cleft lip and palate repair. The findings indicated that PRP/PRF application was associated with a lower incidence of oronasal fistula and reduced scar width compared to controls.
Key findings
- PRP/PRF application was linked to a lower incidence of oronasal fistula compared to controls.
- Scar width was significantly reduced in patients receiving PRP/PRF.
- PRP was associated with accelerated wound healing and faster recovery.
- The evidence quality was low to very low due to small sample sizes and methodological heterogeneity.
Why it matters
Understanding the potential benefits of PRP and PRF in surgical repairs can inform clinical decisions and improve patient outcomes in cleft lip and palate surgeries. Enhanced healing and reduced complications are critical for patient recovery.
What to keep in mind
The certainty of evidence was limited due to small sample sizes and methodological heterogeneity among the included studies.