Association between packed red blood cell transfusion and clinical deterioration in neonatal necrotizing enterocolitis: a systematic review and meta-analysis.
Jinglan Huang, Qian Gao, Ziqing Xu et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis examined the relationship between packed red blood cell (pRBC) transfusion and clinical deterioration in neonates with necrotizing enterocolitis (NEC). Analyzing five studies with 971 neonates, the results indicated a significant association, with an odds ratio of 6.05 (95% CI: 3.02-12.14) for clinical worsening following pRBC transfusion.
Key findings
- The pooled analysis showed an odds ratio of 6.05 for clinical deterioration associated with pRBC transfusion.
- Five studies involving 971 neonates with NEC were included in the analysis.
- The findings suggest a potential link between pRBC transfusion and exacerbation of NEC.
Why it matters
Understanding the potential risks associated with pRBC transfusion in neonates with NEC is crucial for clinicians, as it may influence transfusion practices and patient management strategies in this vulnerable population.
What to keep in mind
The analysis was limited by the small number of eligible studies included, which affects the robustness of the findings.