Efficacy of Multiple Interventions for Moderate to Large Traumatic Tympanic Membrane Perforations: A Systematic Review and Network Meta-Analysis.
Yueyue Cai, Rui Lai, Tingting Zhu et al.
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In 30 seconds
This network meta-analysis evaluated the efficacy of various interventions for moderate to large traumatic tympanic membrane perforations (TTMP) in 1285 patients. The study found that fibroblast growth factor-2 (FGF-2) combined with gelfoam patching significantly improved healing rates and reduced healing times. Ofloxacin otic solution also showed positive effects on healing rates.
Key findings
- FGF-2 combined with gelfoam patching showed the highest efficacy in healing rates and reduced healing times.
- Ofloxacin otic solution positively affected healing rates in patients with TTMP.
- Edge approximation ranked lowest among interventions, indicating limited effectiveness for moderate to large perforations.
Why it matters
Understanding the comparative efficacy of treatments for TTMP can guide clinicians in selecting appropriate interventions, potentially improving patient outcomes in tympanic membrane healing and hearing restoration.
What to keep in mind
The study's findings are exploratory due to geographic homogeneity, a limited number of studies, and methodological constraints.