Paraneoplastic Immunoglobulin A Vasculitis With Rapidly Progressive Glomerulonephritis in a Patient With Metastatic Meningioma: Case Report and Literature Review.
Aryan Jain, Mayur Pabba, Aditya Jain et al.
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Case in brief
A patient with metastatic meningioma presented with relapsing crescentic immunoglobulin A vasculitis with renal involvement, characterized by rapidly progressive glomerulonephritis. The diagnosis of IgAVN was made following the identification of renal symptoms, and the patient was treated with a combination of malignancy-directed therapy and corticosteroids, leading to improved renal outcomes.
Diagnostic / clinical pearl
Clinicians should consider the possibility of underlying malignancy in cases of adult-onset, relapsing, or aggressive immunoglobulin A vasculitis with renal involvement.
Why it matters
Understanding the potential paraneoplastic association of immunoglobulin A vasculitis can aid in timely diagnosis and management, improving patient outcomes.