Extra-appendiceal low-grade mucinous neoplasm-like lesions: clinicopathologic and molecular characteristics.
Soo Hyun Lee, Berk Kaan Aktas, Avery Kim et al.
✦ AI-curated · Sources linked
Case in brief
Three cases of low-grade appendiceal mucinous neoplasm (LAMN)-like lesions were identified in duplication cysts, distinct from the appendix. Histological analysis revealed features characteristic of LAMN, including low-grade mucinous epithelium and mural fibrosis, while molecular testing showed activating KRAS or GNAS mutations. These lesions exhibited no appendiceal involvement, suggesting they are true neoplastic proliferations within cystic compartments.
Diagnostic / clinical pearl
Clinicians should recognize that extra-appendiceal LAMN-like lesions can mimic conventional appendiceal LAMN, necessitating careful evaluation to avoid misclassification.
Why it matters
Understanding the characteristics of these lesions is essential for appropriate staging and management, as they may require similar clinical approaches to conventional appendiceal LAMN.