Image-guided interventional radiotherapy (modern brachytherapy) for treatment of vaginal intraepithelial neoplasia: single-institution experience and systematic literature review and meta-analysis.
Strahlenther OnkolMay 26, 2026 (epub)
V Lancellotta, A P Solazzo, B Fionda et al.
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In 30 seconds
This study evaluated the efficacy and safety of image-guided interventional radiotherapy (IG-IRT) for high-grade vaginal intraepithelial neoplasia (VaIN) through a retrospective case series of 10 patients and a systematic literature review. The 1-year actuarial local control and overall survival rates were both 100%, indicating IG-IRT's effectiveness in this population.
Key findings
- 1-year actuarial local control and overall survival rates were both 100%.
- No acute side effects were recorded during the treatment.
- Late G2 toxicity occurred in four patients, including vaginal stenosis in one and atrophy in four.
Why it matters
The findings suggest that IG-IRT may offer a safe and effective treatment option for high-grade VaIN, a condition with limited management strategies. Clinicians may consider this approach for patients who are poor surgical candidates or have multifocal disease.