Clinical and electrophysiological effects of cathodal high-definition transcranial direct current stimulation to the right superior temporal sulcus in psychosis spectrum disorders: a pilot proof of concept study.
Int Rev PsychiatryMay 26, 2026 (epub)
Clinical ResearchPsychiatry
Rebekah L Trotti, Nicolas Raymond, David A Parker et al.
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In 30 seconds
This randomized controlled trial investigated the effects of cathodal high-definition transcranial direct current stimulation (HD-tDCS) on the right superior temporal sulcus in individuals with psychosis spectrum disorders. The study found that the active stimulation group showed reduced clinician-assessed symptoms at both 5 days and 1 month, indicating potential therapeutic effects and target engagement.
Key findings
- Active stimulation group showed reduced clinician-assessed symptoms at 5 days and 1 month.
- Attenuated audiovisual integration was observed at 5 days in the active group.
- Enhanced auditory steady state response and reduced alpha power over the rSTS were noted at 1 month.
- Self-reported symptoms decreased significantly in the active group at 5 days.
Why it matters
The findings suggest that modulating activity in the right superior temporal sulcus may offer a novel approach to alleviating symptoms in psychosis spectrum disorders, highlighting the potential for non-invasive interventions in psychiatric treatment.