Comparative Efficacy of Intra-Articular Adjuvants Following Double-Needle Arthrocentesis for Intra-Articular Pain and Dysfunction: A Network Meta-Analysis.
Gowri Sivaramakrishnan, Kannan Sridharan, Mohammed Abdulla Al Muharraqi
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In 30 seconds
This network meta-analysis evaluated the efficacy of intra-articular adjuvants following double-needle arthrocentesis in patients with intra-articular pain and dysfunction. The study found that hyaluronic acid plus platelet-rich plasma (HA + PRP) significantly improved maximum mouth opening at 3 months (SMD = 2.12) and 6 months (SMD = 2.07) compared to no adjuvant, indicating its potential benefit in clinical practice.
Key findings
- HA + PRP improved maximum mouth opening at 3 months (SMD = 2.12; P = .0016).
- HA + PRP also improved maximum mouth opening at 6 months (SMD = 2.07; P < .001).
- HA + PRP was the most effective for pain reduction at 3 months (SMD = -3.11; P = .021).
- Platelet-rich fibrin combined with splint therapy ranked highest for pain reduction at 6 months (SMD = -2.53; P = .028).
Why it matters
Understanding the effectiveness of intra-articular adjuvants can guide clinicians in optimizing treatment strategies for patients with intra-articular pain and dysfunction, potentially improving patient outcomes and satisfaction.
What to keep in mind
Substantial heterogeneity was observed across all networks, and there is limited long-term data available.