The impact of adjuvant ultrasound-guided periulcer foam sclerotherapy on venous leg ulcer recurrence: Long-term outcomes.
J Vasc Surg Venous Lymphat DisordMay 26, 2026 (epub)
Rashad A Bishara, Ahmed Gaweesh, Ihab Nabil Hanna et al.
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In 30 seconds
This randomized controlled trial evaluated the long-term effects of ultrasound-guided periulcer foam sclerotherapy (PUFS) on venous leg ulcer (VLU) recurrence in 58 patients over a mean follow-up of 2.2 years. Results showed a significant reduction in recurrence rates, with 12% in the PUFS group compared to 45% in the control group (P = .006).
Key findings
- Ulcer recurrence was 12% in the PUFS group versus 45% in the control group (P = .006).
- The adjusted hazard ratio for recurrence in the PUFS group was 0.20 (95% CI, 0.06-0.75; P = .016).
- Mean ulcer-free time was significantly longer in the PUFS group at 1059 days compared to 736 days in the control group (P = .002).
- Quality of life scores were significantly better in the PUFS group (4.45) compared to the control group (7.94; P = .018).
Why it matters
The findings suggest that incorporating PUFS in the management of venous leg ulcers can significantly reduce recurrence rates and improve patient quality of life, which is crucial for long-term patient outcomes.