Diffuse Large B-Cell Lymphoma Presenting as a Thigh Mass: A Case Report.
Sondos Badran, Karina Basmajian, Alexander T Phan et al.
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Case in brief
A 76-year-old female presented with swelling and pain in her right thigh. Imaging revealed a soft-tissue mass that raised concerns for sarcoma. However, biopsy results confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL). This case highlights the rare occurrence of primary thigh involvement by DLBCL, which can easily be mistaken for other malignancies.
What made this case unusual
Primary involvement of the thigh by diffuse large B-cell lymphoma is exceedingly rare and can mimic sarcoma in both clinical and radiographic presentations.
Diagnostic / clinical pearl
Clinicians should consider lymphoma in the differential diagnosis of extremity masses, particularly when faced with atypical presentations.
Why it matters
This case emphasizes the need for a broad differential diagnosis in evaluating soft-tissue masses, as extranodal presentations of lymphoma can be easily overlooked.