Familial high-risk (FHR) for severe mental illness in clinical high-risk for psychosis (CHR-P): a systematic review and meta-analysis.

In 30 seconds

This systematic review and meta-analysis examined familial high-risk (FHR) factors in individuals at clinical high risk for psychosis (CHR-P). Analyzing 93 independent samples, the study found that 29.9% had a broad family history of psychiatric illness, while 21.0% had a family history of psychosis in first-degree relatives. Notably, a family history of psychosis was negatively associated with the risk of transition to psychosis.

Key findings

• 29.9% of CHR-P individuals had a broad family history of psychiatric illness.
• 21.0% had a family history of psychosis in first-degree relatives.
• 24.6% had a family history of psychosis in either first- or second-degree relatives.
• A family history of psychosis was negatively associated with the risk of transition to psychosis.

Why it matters

Understanding familial high-risk factors is crucial for improving risk stratification and preventive interventions in young individuals at clinical high risk for psychosis. Enhanced reporting and screening of these factors could inform clinical assessments and management strategies.