Should we consider excessive weights in pediatric kidney transplant recepient candidates?: A systematic review and meta-analysis of kidney transplantation outcomes.
Muhammad Asykar Palinrungi, Syarif Syarif, Khoirul Kholis et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of pre-transplant excess weight on post-transplant outcomes in pediatric kidney transplant recipients. Analyzing data from six studies with 65,483 participants, the study found that excess weight significantly increased the risk of acute rejection (OR = 1.09), delayed graft function (OR = 1.17), and graft failure at both 1 year (OR = 1.16) and 5 years (OR = 1.13).
Key findings
- Pre-transplant excess weight was associated with a 9% increased risk of acute rejection (OR = 1.09).
- There was a 17% increased risk of delayed graft function in patients with excess weight (OR = 1.17).
- 1-year graft failure risk was 16% higher in those with excess weight (OR = 1.16).
- 5-year graft failure risk was 13% higher among recipients with excess weight (OR = 1.13).
Why it matters
Understanding the relationship between excess weight and transplant outcomes in pediatric patients is crucial for optimizing pre-transplant evaluations and interventions, potentially improving long-term success rates and patient health.