Advantages of artificial saliva containing Cuminum cyminum and Zingiber officinale on hemodialysis patients with xerostomia: Randomized clinical trials.
Explore (NY)May 22, 2026 (epub)
Supamas Napavichayanun, Nattachai Srisawat, Weerachai Chaijamorn et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy and safety of herbal artificial saliva (HAS) containing cumin and ginger in hemodialysis patients with xerostomia. The study found that HAS significantly improved saliva flow rates (0.06 ± 0.08 g/min vs. 0.02 ± 0.06 g/min, p = 0.04) and reduced dry mouth scores after 14 days compared to placebo.
Key findings
- HAS improved saliva flow rates in HD patients after 7 days compared to placebo (0.06 ± 0.08 g/min vs. 0.02 ± 0.06 g/min, p = 0.04).
- Dry mouth scores were significantly lower in the HAS group after 14 days compared to placebo (p = 0.024).
- HAS was found to be safe for use in both healthy volunteers and HD patients.
Why it matters
Xerostomia is a common issue in hemodialysis patients, impacting their quality of life. Effective management options are limited, making the findings on HAS particularly relevant for improving patient care in this population.