FDG-PET/CT Parameters for distinguishing high and low microsatellite instability in colorectal cancer: A systematic review and Meta-analysis.
Nima Broomand Lomer, Sajjad Sadeghpour, Drew A Torigian
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of FDG-PET/CT parameters in distinguishing high microsatellite instability (MSI-H) from low microsatellite instability (MSI-L) in colorectal cancer (CRC) patients. Among 1,579 patients, volumetric measures like metabolic tumor volume (MTV) demonstrated significant discriminatory power (SMD: 0.67; 95% CI: 0.41 to 0.93), suggesting potential utility in noninvasive MSI assessment.
Key findings
- MTV showed significant discriminatory power with an SMD of 0.67 (95% CI: 0.41 to 0.93).
- TLG also demonstrated significant differences with an SMD of 0.37 (95% CI: 0.13 to 0.60).
- SUVmax and SUVmean did not show significant differences between MSI groups.
- MTV had the highest diagnostic performance with an AUC up to 0.805.
Why it matters
Understanding the noninvasive differentiation of MSI status in colorectal cancer can aid in treatment planning, particularly for immunotherapy. This study highlights the potential of PET-derived volumetric parameters as adjunctive tools in clinical practice.