Valproate-induced acute necrotising pancreatitis in a young woman with bipolar disorder: Sustained remission after switch to lithium.
Romil Saini, Prabhat Kumar Verma, Praveer Rai
✦ AI-curated · Sources linked
Case in brief
A young woman with bipolar disorder on valproate developed acute necrotising pancreatitis. Following prompt discontinuation of the medication and conservative management, her condition improved. She was subsequently switched to lithium and has remained stable without recurrence for 30 months. This case underscores the need for early recognition and coordinated care in managing such adverse effects.
Diagnostic / clinical pearl
Clinicians should be aware that valproate can induce acute necrotising pancreatitis in adults, necessitating immediate drug withdrawal and careful management.
Why it matters
This case emphasizes the importance of cross-disciplinary collaboration in managing adverse drug reactions while maintaining psychiatric stability.