Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records.
Michele Fornaro, Chiara Di Lorenzo, Luca Steardo et al.
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In 30 seconds
This meta-analysis reviewed 81 studies involving over 254 million records to assess the prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders. Key findings include a 61.8% prevalence of major depressive disorder in diabetes mellitus and a relative risk of 1.48 for all-cause mortality in comorbid major depressive disorder among diabetic patients. The study emphasizes the need for integrated care.
Key findings
- Major depressive disorder prevalence in diabetes mellitus was 61.8% (95%C.I.=56.6-66.7%).
- Comorbid major depressive disorder increased all-cause mortality risk (RR=1.48, 95%C.I.=1.4-1.6).
- Diabetes raised the risk of 30-day hospital readmission in dementia patients (RR=1.2, 95%C.I.=1.1-1.3).
- Vitamin D deficiency prevalence in schizophrenia was 65.3% (95%C.I.=46.4-84.2%).
Why it matters
Understanding the prevalence and outcomes of comorbid psychiatric and metabolic disorders is crucial for clinicians, as it highlights the complexity of patient care and the necessity for multidisciplinary approaches to improve treatment outcomes.