Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.
Sonda Jallouli, Dana Jallouli, Choumous Kallel et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial investigated the effects of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in 49 patients with multiple sclerosis (PwMS). The study found that the combination of training and melatonin significantly improved antioxidant levels and reduced inflammatory markers compared to training alone, with notable changes in body composition.
Key findings
- TMG group showed increased levels of reduced glutathione, total bilirubin, and uric acid compared to TPG and MG (all: p < 0.001).
- Malondialdehyde and low-density lipoprotein cholesterol levels decreased in TMG compared to TPG (p < 0.001) and MG (p < 0.001).
- Lean mass increased (p = 0.025) while fat mass decreased (p = 0.0013) in TMG compared to TPG.
Why it matters
The findings suggest that combining self-paced training with melatonin supplementation may enhance treatment outcomes for patients with multiple sclerosis by improving oxidative stress and inflammation, which are critical factors in disease management.