12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial.
J Int Soc Sports NutrMay 31, 2026 (epub)
Mehran Alipour, Ayoub Saeidi, Keyvan Hejazi et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial investigated the effects of fisetin supplementation combined with interval resistance and aerobic training on inflammatory markers and insulin resistance in 44 obese men. After 12 weeks, significant improvements were observed in Maresin-1 levels and reductions in pro-inflammatory markers and insulin resistance, particularly in the group receiving both training and fisetin supplementation.
Key findings
- Maresin-1 levels increased significantly in the training-placebo and training-fisetin groups (p = 0.001).
- IL-6 decreased in the training, training-fisetin, and fisetin groups (p = 0.001, 0.001, and 0.013, respectively).
- Fasting blood glucose, insulin, and HOMA-IR decreased significantly in all active intervention groups (p = 0.003).
- The greatest reductions in metabolic markers were observed in the training-fisetin group.
Why it matters
The findings suggest that combining fisetin supplementation with exercise may enhance inflammatory resolution and metabolic control in obese individuals, potentially offering a non-pharmacological approach to reduce obesity-related health risks.