Histotripsy-Induced Acute Kidney Injury Following Liver Tumor Treatment: A Preliminary Report of 9 Cases.
Lexiana L Poe, Adrienne L Kisting, Mishal Mendiratta-Lala et al.
✦ AI-curated · Sources linked
Case in brief
This report details nine patients who developed acute kidney injury (HAKI) following histotripsy treatment for liver tumors. The incidence of HAKI was observed in 6.2% of the 146 procedures performed across five medical centers. Notably, discrepancies were found between planned and actual treatment volumes, with some patients experiencing significant adverse events. The presence of brown urine post-treatment was noted as a potential predictive indicator.
What made this case unusual
The significant discrepancy between planned treatment volumes (22.3 mL) and actual volumes (58.3 mL) raises concerns about treatment protocols and their impact on renal outcomes.
Diagnostic / clinical pearl
Clinicians should be aware that brown urine following histotripsy may indicate acute kidney injury, and careful monitoring of treatment volumes is essential to mitigate risks.
Why it matters
Understanding the relationship between treatment volume discrepancies and acute kidney injury can inform safer histotripsy practices and improve patient outcomes.