Repetitive Transcranial Magnetic Stimulation (rTMS) for Adolescent Depression: A Systematic Review and Meta-Analysis of Treatment Response and Suicidal Ideation Reduction.
Lidija Rakic, Floris Tas, Miao Chen et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for treating major depressive disorder in adolescents. Nineteen studies were included, revealing a pooled standardized mean change in depression severity of -2.15 (95% CI [-2.58, -1.73]). The response rate was 54% (95% CI [42%; 66%]), indicating rTMS may be beneficial for this population.
Key findings
- The pooled standardized mean change in depression severity was -2.15 (95% CI [-2.58, -1.73]).
- The response rate for rTMS treatment was 54% (95% CI [42%; 66%]).
- A large reduction in suicidal ideation was observed with a pooled standardized mean change of -2.78, though not statistically significant.
- Mild and transient adverse effects were reported across the studies.
Why it matters
Given the high prevalence of major depressive disorder in adolescents and the associated risk of relapse, effective treatment options like rTMS could significantly improve outcomes and reduce suicidal ideation in this vulnerable population.
What to keep in mind
The majority of studies included were rated as having a high risk of bias, and there was high heterogeneity in methods.