Intranasal verrucous carcinoma with autoinoculation from benign warts in the context of locus minoris resistentiae.
Simona Kordeva, Konstantin Georgiev Tchernev, Valentina Broshtilova et al.
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Case in brief
A 50-year-old male presented with verrucous carcinoma in the left nasal vestibule, likely arising from autoinoculation of HPV from a prior facial wart at the site of nasal trauma. The patient had a history of partial septal cartilage resection, with cicatricial tissue present. The exophytic lesion was surgically excised and electrocauterized, with no residual tumor observed. Histopathology revealed koilocytosis and p16 overexpression, supporting HPV's role in the carcinoma's pathogenesis.
Diagnostic / clinical pearl
Clinicians should consider the potential for verrucous carcinoma to develop in the nasal mucosa, particularly in patients with a history of HPV-related lesions and prior nasal trauma.