Systemic oxidative stress in children and adolescents with attention deficit hyperactivity disorder: a meta-analysis of oxidative and antioxidant biomarkers.
Patricia Marest Suwindi, Ikbal Andrian Malau, Kuan-Pin Su et al.
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In 30 seconds
This meta-analysis examined oxidative stress and antioxidant biomarkers in 1,325 children and adolescents with ADHD compared to 1,272 healthy controls. The study found significantly higher blood levels of total oxidant status (TOS) and urinary 8-hydroxy-deoxyguanosine (8-OHdG) in ADHD patients, alongside lower blood total antioxidant status (TAS). The analysis utilized standardized mean differences (SMDs) to assess biomarker levels across 20 studies.
Key findings
- ADHD patients had higher blood TOS levels (SMD = 0.94; p < 0.00001) compared to controls.
- Urinary 8-OHdG levels were also higher in ADHD patients (SMD = 0.21; p = 0.004).
- Blood TAS levels were lower in ADHD patients (SMD = -0.53; p = 0.02).
- No significant differences were found in blood levels of 8-OHdG, MDA, or NO.
Why it matters
Understanding the role of oxidative stress in ADHD may inform future therapeutic strategies and interventions. Clinicians should consider the implications of oxidative biomarkers in the management of ADHD.