Androgen therapy and musculoskeletal health in older adults: An umbrella review.
SemergenJun 3, 2026 (epub)
P P López Hilario, V R Gabiati Niedo, K S Khan et al.
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In 30 seconds
This umbrella review synthesized evidence from 11 systematic reviews and meta-analyses of randomized clinical trials assessing androgen therapy in older adults (≥60 years). The study found that testosterone therapy significantly improved lean body mass by 1.6kg to 3.59kg and muscle strength, particularly in leg press and leg extension, without adverse cardiovascular effects. The review included 20,846 male participants.
Key findings
- Testosterone therapy increased lean body mass by 1.6kg to 3.59kg.
- Maximal lower-limb strength improvement was noted in leg press (91.23 Newtons).
- No significant effects on major cardiovascular events or all-cause mortality were observed.
Why it matters
Understanding the effects of testosterone therapy on muscle health in older adults is crucial for managing age-related declines in strength and body composition, which can impact overall health and quality of life.