Sudden Acute Liver Failure in Citrullinemia Type 1: An Argument for Earlier Liver Transplantation?

J PediatrJun 2, 2026 (epub)
Case ReportGastroenterologyPediatrics

Jessica A Eldredge, Anil Dhawan, Maesha Deheragoda et al.

✦ AI-curated · Sources linked

Case in brief

This report details a case of a child with citrullinemia type 1 who presented with sudden acute liver failure. Despite medical management, the child experienced recurrent hepatic decompensations, ultimately necessitating emergency liver transplantation. This case highlights the potential for severe liver complications in citrullinemia type 1 and the need for timely intervention.

Diagnostic / clinical pearl

Clinicians should be aware that citrullinemia type 1 can lead to acute liver failure and may require early referral for liver transplantation in severe cases.

Why it matters

This case underscores the importance of recognizing the potential for acute liver failure in citrullinemia type 1, which may prompt earlier surgical intervention.

Source

PubMed · PMID 42235881

Published in J Pediatr. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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