Cystic Panfolliculoma of the Eyelid.
Alan D Proia, Christopher R Dermarkarian, Michelle M Schneider
✦ AI-curated · Sources linked
Case in brief
A woman in her early 90s had a painless, crateriform lesion at the left eyelid and lower eyebrow that had worsened over approximately 1 year, fluctuated in size, and sometimes shed a scab with drainage. Excisional biopsy showed a well-demarcated dermal cyst connected to the epidermis, with cells demonstrating multiple stages of follicular differentiation, including infundibular, inner sheath, and hair differentiation. There was no cytological atypia or fully mature hair follicle formation. The lesion was diagnosed as cystic panfolliculoma; the report notes that these benign neoplasms do not recur locally after complete excision.
What made this case unusual
The lesion was a cystic panfolliculoma arising on the eyelid, an uncommon site for this histological variant. Its cyst contents and wall showed a broad range of follicular differentiation.
Diagnostic / clinical pearl
A cystic eyelid lesion can represent panfolliculoma; diagnosis depends on recognizing multiple lines of follicular differentiation in the cyst contents and wall.