Efficacy of non-pharmacological interventions on central sensitisation to pain: A systematic review and network meta-analysis.
Int J Nurs StudMay 30, 2026 (epub)
Clinical ResearchPhysical Medicine & Rehabilitation
Wen-Wen Hua, Xin-Yi Feng, Miao Xin et al.
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In 30 seconds
This systematic review and network meta-analysis evaluated the efficacy of non-pharmacological interventions on central sensitisation in adults with chronic pain. Among 42 trials involving 2811 participants, pain neuroscience education showed a significant effect on pressure pain threshold (SMD = 4.0; 95% CrI: 2.7 to 5.3), while its effect on the Central Sensitisation Inventory was less certain.
Key findings
- Pain neuroscience education had a large, statistically significant effect on pressure pain threshold (SMD = 4.0; 95% CrI: 2.7 to 5.3).
- The effect of pain neuroscience education on the Central Sensitisation Inventory was large but included the null (SMD = -1.5; 95% CrI: -3.2 to 0.27).
- No statistically significant inconsistency or publication bias was detected in the analysis.
- Confidence in Network Meta-Analysis indicated high-certainty evidence for pressure pain threshold outcomes.
Why it matters
Understanding the effectiveness of non-pharmacological interventions for central sensitisation can guide clinicians in developing comprehensive pain management strategies, particularly in chronic pain populations where traditional pharmacological approaches may be limited.