Symptom profiles at baseline are associated with remission in major depression: a confirmatory analysis of the PANDORA trial.
J Psychiatr ResMay 30, 2026 (epub)
Clinical ResearchPsychiatry
Maria Luca, Alessandro Serretti, Stefano Barlati et al.
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In 30 seconds
This randomized controlled trial analyzed 215 adults with Major Depressive Disorder (MDD) from the PANDORA trial to assess the relationship between baseline depressive symptom profiles and remission. The study found that 53% of patients achieved remission by week 12. Higher baseline scores on the Hamilton Depression Rating Scale (HAM-D) were linked to lower odds of remission.
Key findings
- 53% of patients achieved remission by week 12.
- Higher baseline HAM-D total scores were associated with lower odds of remission.
- In women, higher scores on suicide and psychomotor retardation were linked to non-remission.
- In men, hypochondriasis was the only significant prognostic marker for non-remission.
Why it matters
Understanding the association between baseline symptom profiles and remission can help clinicians tailor treatment strategies for patients with MDD, potentially improving outcomes through symptom-guided approaches.