Time-restricted eating versus dietetic guidance on glycaemic outcomes in adults at risk of type 2 diabetes: a non-inferiority randomised clinical trial.
DiabetologiaJun 6, 2026 (epub)
Evelyn B Parr, Rasha Charrouf, Amy T Hutchison et al.
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In 30 seconds
This non-inferiority randomized clinical trial evaluated the effects of time-restricted eating (TRE) compared to individualized dietetic guidance (IDG) on HbA1c levels in 247 adults at risk of type 2 diabetes over 4 months. TRE was found to be non-inferior to IDG for HbA1c change (mean difference: -0.22 mmol/mol), but not superior. At 12 months, non-inferiority could not be concluded.
Key findings
- At 4 months, TRE showed a mean HbA1c change of -0.22 mmol/mol compared to IDG.
- At 12 months, the upper bound of the HbA1c difference exceeded the non-inferiority margin.
- Both interventions resulted in small and not clinically meaningful changes in HbA1c.
- Adverse events were minor and similar between TRE and IDG.
Why it matters
Understanding the effectiveness of TRE as an alternative to traditional dietetic guidance is crucial for managing patients at risk of type 2 diabetes, especially when access to dietitians is limited.