Effect of intraoperative ketamine on pain, opioid use, and psychological recovery in orthopedic trauma patients (KOPM trial): protocol for a randomized, single-blind trial.
Pain ManagJun 6, 2026 (epub)
Clinical ResearchOrthopedic Surgery
Camas Curran, Evan J Hernandez, Jennifer Hudnall et al.
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In 30 seconds
The KOPM trial is a randomized, single-blind study assessing the effects of intraoperative ketamine on pain, opioid use, and psychological recovery in 90 orthopedic trauma patients. The study aims to evaluate postoperative pain via the Visual Analog Scale (VAS), opioid consumption in morphine milligram equivalents (MME), and psychological recovery using the PHQ-9 and PCL-5 assessments.
Key findings
- Ketamine is administered as a 0.5 mg/kg IV bolus during surgery.
- Outcomes will be measured at multiple time points: 1-7 days, 2-3 weeks, 6 weeks, 3 months, and 6 months postoperatively.
- The study addresses pain control and psychological recovery in polytraumatized orthopedic patients.
Why it matters
This research is significant as it explores a potential intervention that may improve both pain management and psychological outcomes in a population often facing inadequate treatment for these issues.