Polyostotic Fibrous Dysplasia Mimicking Widespread Skeletal Metastases on 68 Ga-PSMA PET/CT and Demonstrating a Superscan Pattern on Bone Scintigraphy.
Muhammet Halil Baltacioglu, Lasif Turker Serdar, Mehmet Bayram Cakir
✦ AI-curated · Sources linked
Case in brief
A 63-year-old man with newly diagnosed prostate cancer underwent 68 Ga-PSMA PET/CT for staging, which revealed widespread skeletal uptake suggestive of metastatic disease. Bone scintigraphy showed a superscan pattern. However, CT imaging displayed benign features such as ground-glass appearance and preserved cortical integrity, leading to a diagnosis of fibrous dysplasia confirmed by histopathology.
What made this case unusual
The case illustrates how fibrous dysplasia can mimic widespread skeletal metastases on 68 Ga-PSMA PET/CT, presenting a diagnostic challenge.
Diagnostic / clinical pearl
Clinicians should be aware that fibrous dysplasia can exhibit increased 68 Ga-PSMA uptake, potentially leading to misinterpretation as metastatic disease.
Why it matters
This case underscores the necessity of correlating metabolic imaging findings with CT morphology to prevent misdiagnosis and inappropriate staging.