High Somatostatin Receptor Expression in Alveolar Soft Part Sarcoma Detected by 68 Ga-DOTATOC PET/CT.
Tine Gregersen, Hanne Krogh Rose, Steen Bærentzen et al.
✦ AI-curated · Sources linked
Case in brief
A patient with alveolar soft part sarcoma (ASPS) was evaluated for a suspected pancreatic neuroendocrine tumor using FDG-PET/CT, which was inconclusive. Subsequent DOTATOC PET revealed no uptake in the pancreas but demonstrated significant uptake in the primary ASPS located in the scapula and identified previously unrecognized metastases in the breast and skull. This finding suggests high somatostatin receptor expression in ASPS.
What made this case unusual
This case is notable for the first report of DOTATOC uptake in ASPS, highlighting a potential for SSTR-targeted therapies.
Diagnostic / clinical pearl
Clinicians should consider the possibility of high somatostatin receptor expression in ASPS, which may influence treatment options.
Why it matters
The identification of SSTR expression in ASPS could open avenues for targeted therapies, such as 177 Lu-DOTATATE, enhancing treatment strategies for this rare sarcoma.