More Impressive 18 F-FDG PET/CT Findings Than 68 Ga-DOTA-FAPI-04 in a Cervical Chordoma.
Tingting Xu, Ke Cheng, Ya Liu et al.
✦ AI-curated · Sources linked
Case in brief
An 81-year-old woman presented with a cervical chordoma affecting the C1-C5 vertebrae. Imaging revealed significant 18 F-FDG uptake, contrasting with minimal accumulation of 68 Ga-DOTA-FAPI-04. This discrepancy in imaging findings suggests variability in FAPI uptake in chordomas, possibly due to tumor microenvironment factors or histologic differences.
What made this case unusual
The case highlights a notable discordance between 18 F-FDG and 68 Ga-DOTA-FAPI-04 imaging in a cervical chordoma, which is atypical for tumor imaging.
Diagnostic / clinical pearl
Clinicians should be aware that FAPI-targeted PET/CT may show heterogeneous uptake in chordomas, which could affect diagnostic interpretation.
Why it matters
Understanding the variability in imaging uptake can guide clinicians in the interpretation of PET/CT results and influence management decisions for chordoma patients.