Management of gynecomastia in adolescence and adults: the clinical practice guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS).

J Endocrinol InvestJun 8, 2026 (epub)
Clinical ResearchEndocrinologyPlastic SurgeryPsychiatryOpen access

Carlotta Pozza, Riccardo Selice, Arcangelo Barbonetti et al.

✦ AI-curated · Sources linked

In 30 seconds

The Italian Society of Andrology and Sexual Medicine (SIAMS) developed clinical practice guidelines for managing gynecomastia in adolescents and adults. This systematic review emphasizes a structured approach to diagnosis and treatment, recommending observation for recent-onset cases and surgery for long-standing conditions. The guidelines aim to standardize care and address the psychological impact of gynecomastia.

Key findings

  • Observation is recommended for physiological or recent-onset gynecomastia cases.
  • Pharmacological therapy may be considered for selected idiopathic or painful forms.
  • Surgery is indicated for long-standing fibrotic gynecomastia or significant psychological distress.
  • Psychological support is advised, particularly for adolescents.

Why it matters

Standardized guidelines for gynecomastia management can improve patient outcomes by ensuring consistent, evidence-based care. Addressing both physical and psychological aspects is crucial for effective treatment.

Source

PubMed · PMID 42258023Free full text on PubMed Central

Published in J Endocrinol Invest. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Endocrinology

Clinical ResearchHematology

Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.

This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.

N Engl J MedOct 15, 2026Read summary
Clinical ResearchHematology

Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.

RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…

LancetOct 24, 2026Read summary
Clinical ResearchRheumatology

Ianalumab for the Treatment of Patients with Sjögren's Disease.

Two 52-week, double-blind, randomized, placebo-controlled phase III trials evaluated monthly or less frequent ianalumab in patients with active Sjögren's disease.

N Engl J MedOct 22, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.