Vertical Sleeve Gastrectomy Versus Comprehensive Lifestyle Intervention for Adolescents With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Controlled Cohort Study.
Toshifumi Yodoshi, Nicholas J Ollberding, Meghan McNeill et al.
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In 30 seconds
This prospective controlled cohort study compared the effects of vertical sleeve gastrectomy (VSG) and comprehensive lifestyle intervention (CLI) on adolescents aged 12-19 with severe obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). VSG was associated with significantly greater histological improvement, including a 68% higher probability of NAS improvement compared to CLI after 52 weeks.
Key findings
- VSG resulted in a 68% higher probability of NAS improvement compared to CLI (RD 0.68, 95% CI 0.45-0.91).
- Fibrosis improvement was 36% more likely with VSG than CLI (RD 0.36, 95% CI 0.12-0.59).
- Complete MASLD resolution occurred 49% more often in the VSG group (RD 0.49, 95% CI 0.26-0.72).
- VSG led to a 19.6% reduction in percent weight compared to CLI.
Why it matters
This study provides important evidence for clinicians regarding the effectiveness of VSG over lifestyle interventions in improving histological outcomes in adolescents with severe obesity and MASLD, potentially guiding treatment decisions in this population.