Secretory carcinoma of the breast: a report of six cases with different immunophenotypes and molecular subtypes.
María Ángeles López-García, Lourdes Galán, Blas Meléndez et al.
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Case in brief
This report details six cases of secretory carcinoma of the breast, a rare subtype typically associated with a favorable prognosis. Each case exhibited the characteristic histological features, including solid, microcystic, and tubular patterns, along with secretory material. Notably, the cases displayed varying expressions of HER2 and hormone receptors, suggesting a broader variability in molecular subtypes than previously recognized.
Diagnostic / clinical pearl
Clinicians should be aware that secretory carcinoma can present with diverse immunophenotypes, which may influence treatment strategies despite its generally favorable prognosis.
Why it matters
Understanding the variability in molecular subtypes of secretory carcinoma can lead to more personalized therapeutic approaches, enhancing patient management.