Doege-Potter syndrome caused by a solitary fibrous tumor arising from the greater omentum: a case report.
Tomoki Takizawa, Tatsuya Shonaka, Chikayoshi Tani et al.
✦ AI-curated · Sources linked
Case in brief
An 83-year-old woman had recurrent hypoglycemic episodes associated with a large primary solitary fibrous tumor of the greater omentum. During hypoglycemia, serum insulin was low and adrenocortical hormone levels were normal, making insulinoma and adrenal insufficiency less likely; imaging suggested a solitary fibrous tumor. After open resection, the hypoglycemia resolved immediately. Histopathology confirmed a high-risk solitary fibrous tumor, and Western blot analysis showed reduced high-molecular-weight IGF-II in postoperative serum, supporting its role in the hypoglycemia. At 6 months, neither tumor nor hypoglycemia had recurred.
What made this case unusual
The tumor arose primarily in the greater omentum, an exceedingly rare site for a solitary fibrous tumor, and caused Doege-Potter syndrome through tumor-derived high-molecular-weight IGF-II.
Diagnostic / clinical pearl
In a patient with an intra-abdominal tumor and hypoglycemia, low insulin with normal adrenocortical hormone levels should prompt consideration of non-islet cell tumor hypoglycemia, including Doege-Potter syndrome.