Neoplasms in prune belly syndrome: A novel case of early-onset metastatic bladder carcinoma and systematic review of reported tumors.
Lorena Cristina São Leão Ribeiro, Caio Felipe Araujo Matalani, Rafael Nascimento Vilares et al.
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Case in brief
A 33-year-old man with Prune Belly Syndrome (PBS) presented with metastatic muscle-invasive urothelial carcinoma. Despite advances in care for PBS, he developed this aggressive malignancy, which is noted to occur at younger ages in this population. Unfortunately, he died shortly after diagnosis, highlighting the serious long-term risks associated with PBS.
Diagnostic / clinical pearl
Clinicians should be aware that patients with Prune Belly Syndrome may develop malignancies, such as bladder carcinoma, at younger ages and with more aggressive behavior than typically seen in the general population.
Why it matters
This case underscores the importance of long-term follow-up in PBS patients to monitor for potential malignancies, even though routine invasive screening is not recommended.