Comparative effectiveness of preoperative prehabilitation modalities for postoperative recovery in colorectal cancer: A systematic review and network meta-analysis.
Xin Xiang, Qingxin Chen, Yang Yu
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and network meta-analysis evaluated the effectiveness of various preoperative prehabilitation modalities on postoperative recovery in colorectal cancer patients. Among 1545 patients from 22 randomized controlled trials, prehabilitation significantly improved postoperative 6-minute walk distance (6MWD) compared to usual care (SMD, 0.18; 95% CI, 0.05-0.31). The combined exercise, nutrition, and psychological support approach (EX+NU+PSY) showed the highest improvement in 6MWD.
Key findings
- Preoperative prehabilitation improved postoperative 6MWD compared to usual care (SMD, 0.18; 95% CI, 0.05-0.31).
- EX+NU+PSY ranked highest for 6MWD improvement, superior to usual care (SMD, 0.24; 95% CI, 0.02-0.46).
- No significant effects were observed for length of hospital stay (SMD, -0.06; 95% CI, -0.28 to 0.16).
- Limited evidence was found regarding quality of life, anxiety, and depression outcomes.
Why it matters
Understanding the effectiveness of prehabilitation modalities can guide clinicians in optimizing perioperative care for colorectal cancer patients, potentially enhancing functional recovery and patient outcomes.