Feasibility of treating neuroendocrine prostate cancer with anti-SSTR radioligands: A systematic review of imaging and treatment studies.

Semin Nucl MedJun 10, 2026 (epub)
Clinical ResearchOncology (Medical)Radiology (Diagnostic)Endocrinology

Parya Valizadeh, Payam Jannatdoust, Mehrnoosh Shahgholianghahfarokhi et al.

✦ AI-curated · Sources linked

Condensed from the publisher's abstract. An xxcode editorial summary of this publication has not been generated yet.

From the abstract

To review clinical evidence on somatostatin receptor (SSTR) targeted imaging and SSTR directed radioligand therapy in neuroendocrine prostate cancer (NEPC).

Reported results

Of 1937 records, 41 studies were included (4 prospective cohorts and 37 case reports or series). Case reports or series reported 80 patients with SSTR imaging. Cohort studies used 111In based SSTR scintigraphy (three cohorts) or 68Ga-DOTATATE PET/CT (one cohort) and reported SSTR uptake in a minority of patients with heterogeneity across metastatic sites.

Authors' conclusions

SSTR expression in NEPC is heterogeneous. SSTR imaging can support phenotyping and selection for SSTR directed therapy in selected patients, including PSMA low disease, but prospective validation with standardized reporting is needed.

Source

PubMed · PMID 42264967

Published in Semin Nucl Med. The text above is extracted from the publisher's own abstract and has not been edited by xxcode. For clinical decisions, review the original publication.

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