Simulated daylight versus conventional PDT for mild to moderate actinic keratoses: A randomized controlled trial.
Alexandra Sjöholm, Eva Backman, Maja Modin et al.
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In 30 seconds
This randomized controlled trial evaluated the effectiveness and pain perception of simulated daylight photodynamic therapy (SDL-PDT) versus conventional photodynamic therapy (C-PDT) in 69 adults with mild to moderate actinic keratoses (AKs). After one year, SDL-PDT demonstrated a clearance rate of 71.0%, significantly lower than C-PDT's 85.3% (p < 0.001), indicating SDL-PDT is not non-inferior. However, SDL-PDT was associated with significantly less pain.
Key findings
- SDL-PDT had a clearance rate of 71.0% compared to 85.3% for C-PDT (p < 0.001).
- Pain during C-PDT was significantly higher with a mean NRS score of 6.6 versus 0.8 for SDL-PDT (p < 0.001).
- 98.3% of patients preferred SDL-PDT immediately after treatment.
Why it matters
Understanding the balance between treatment effectiveness and patient comfort is crucial in managing actinic keratoses. This study highlights the importance of patient preferences in treatment decisions, particularly for those who prioritize tolerability.