A "Double-Hit" Lymphoma With Plasmablastic Features and Aberrant Keratin Expression Likely Transforming From Follicular Lymphoma.

Int J Surg PatholJun 10, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)HematologyOncology (Medical)

Adam Lyle, Jay L Patel, Girish Venkataraman et al.

✦ AI-curated · Sources linked

Case in brief

A patient with a history of follicular lymphoma developed a transformed lymphoma with plasmablastic features and aberrant keratin expression. Work-up identified MYC and BCL2 rearrangements, establishing a double-hit lymphoma. The keratin expression and plasmablastic morphology complicated classification, but immunohistochemistry and molecular studies, interpreted alongside the clinical history, supported the diagnosis.

What made this case unusual

The transformed lymphoma combined plasmablastic features and aberrant keratin expression with MYC and BCL2 rearrangements, creating a diagnostic pitfall in a patient with prior follicular lymphoma.

Diagnostic / clinical pearl

Aberrant keratin expression does not by itself settle the lineage of a lymphoma; integrate morphology and immunohistochemistry with molecular findings and the patient’s clinical history.

Source

PubMed · PMID 42267449

Published in Int J Surg Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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