Analgesic effect of premixed nitrous oxide in postoperative rehabilitation for ankle fractures: a randomized controlled trial.
Ann MedJun 10, 2026 (epub)
Xueling Qiu, Fei Wang, Yuchen Wang et al.
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In 30 seconds
This randomized controlled trial evaluated the analgesic effect of 65% nitrous oxide compared to 100% oxygen in 100 patients undergoing postoperative rehabilitation for ankle fractures. The study found that pain scores were significantly lower in the nitrous oxide group, with a median difference of -3.0 at T1 and -2.0 at T2 (p < 0.001).
Key findings
- Pain scores were significantly lower in the nitrous oxide group than in the oxygen group (T1: median difference -3.0, T2: median difference -2.0).
- Both therapists and participants reported significantly higher satisfaction levels with nitrous oxide (p < 0.001).
- No severe adverse effects were observed in either group.
- Anxiety scores did not differ significantly between the two groups (p = 0.31).
Why it matters
Effective pain management during rehabilitation is crucial for recovery after ankle fractures. This study suggests that nitrous oxide can provide significant analgesic benefits, enhancing patient satisfaction and potentially improving rehabilitation outcomes.