Examining neuroretinal alterations in autism spectrum disorder: a systematic review of OCT and OCT-A studies.
Int J Psychiatry Clin PractJun 11, 2026 (epub)
David Vaquero-Puyuelo, Ana Boned-Murillo, Concepción De-la-Cámara et al.
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In 30 seconds
This systematic review examined neuroretinal alterations in individuals with Autism Spectrum Disorder (ASD) using Optical Coherence Tomography (OCT) and OCT Angiography (OCT-A). The review found significant differences in retinal parameters, including macular thickness and RNFL thickness, between individuals with ASD and neurotypical controls. These findings suggest potential biomarkers for early detection of ASD.
Key findings
- Individuals with ASD showed differences in macular thickness and volume compared to neurotypical controls.
- Retinal nerve fiber layer (RNFL) thickness and volume were altered in ASD patients.
- Changes in vascular perfusion and vessel density were observed in the ASD population.
- Certain neuroretinal changes correlated with clinical measures of ASD features.
Why it matters
Understanding neuroretinal alterations in ASD could lead to the identification of biological markers that enhance diagnostic accuracy and monitoring. This may improve early intervention strategies and patient outcomes.