Skin Lesion Reconstruction in Graft Versus Host Disease Using Autograft From the Bone Marrow Donor Panniculectomy Tissue.
Daniella King, Maria Kalogeromitros, Barite Gutama et al.
✦ AI-curated · Sources linked
Case in brief
A pediatric patient with a history of Ph-like B-cell acute lymphoblastic leukemia developed chronic graft-versus-host disease (cGVHD) affecting the skin after a haploidentical bone marrow transplant. Conventional treatments failed, and he experienced multidrug-resistant infections. The patient underwent split-thickness skin allograft transplantation using tissue from his mother's pannus, resulting in significant wound resolution within 3 months.
What made this case unusual
The use of skin allograft from the donor's pannus in the context of donor tolerance is a notable aspect of this case, as it leverages the immunologic compatibility established by the prior bone marrow transplant.
Diagnostic / clinical pearl
Clinicians should consider donor skin allografting as a potential treatment for refractory cutaneous cGVHD, especially when donor tolerance is established.
Why it matters
This case underscores the importance of exploring innovative surgical options in managing complex complications of cGVHD, particularly in pediatric patients.