High-Intensity Focused Ultrasound Versus Robot-Assisted Radical Prostatectomy for Localized Prostate Cancer: A Systematic Review and Meta-Analysis of Oncologic and Functional Outcomes.
Si Ge, Zhiqiang Zeng, Lei Zheng
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In 30 seconds
This systematic review and meta-analysis compared functional and oncologic outcomes of high-intensity focused ultrasound (HIFU) and robot-assisted radical prostatectomy (RARP) in 2123 patients with localized prostate cancer. HIFU demonstrated significantly higher International Index of Erectile Function (IIEF)-5 scores at 6, 12, and 24 months, and improved urinary continence rates compared to RARP, with no significant differences in IPSS or salvage therapy rates.
Key findings
- HIFU showed higher IIEF-5 scores at 6 months (effect, 3.41; 95% CI, 1.88-4.94).
- At 12 months, IIEF-5 scores for HIFU were also significantly higher (effect, 3.75; 95% CI, 3.00-4.49).
- HIFU was associated with better urinary continence (OR, 0.40; 95% CI, 0.27-0.59).
- No significant differences were found in IPSS or salvage therapy rates.
Why it matters
Understanding the comparative effectiveness of HIFU and RARP is crucial for clinicians managing localized prostate cancer, as it informs treatment decisions that can impact patients' quality of life and functional outcomes.