Comparison of posterior cellular bonegraft options for single-level lumbar spinal fusion: a randomized trial.
Spine JJun 12, 2026 (epub)
Clinical ResearchOrthopedic Surgery
Glenn R Buttermann
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial evaluated the effectiveness of six types of bone graft materials for single-level lumbar spinal fusion in 175 patients. The study found that iliac bone autograft (IBG) and bone morphogenic protein (BMP) had the highest fusion rates at 98% and 94%, respectively, while various allograft options showed lower rates. Overall, outcomes improved across all groups.
Key findings
- Fusion rates were 98% for IBG, 94% for BMP, and 85% for BMA.
- Allograft MSC options had fusion rates ranging from 50% to 67%.
- All groups showed significant improvement in pain and disability scores postoperatively.
- BMP was identified as the most expensive graft material.
Why it matters
Understanding the comparative effectiveness of different bone graft materials can guide clinicians in selecting options that optimize patient outcomes while considering cost and potential complications associated with graft harvesting.