Timing of carbetocin administration in vaginal deliveries: a double-blind, randomized controlled trial.
J Perinat MedJun 10, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Pınar Yıldız, Esra Keles, Gazi Yıldız et al.
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In 30 seconds
This randomized controlled trial evaluated the timing of carbetocin administration in 160 primiparous women during vaginal deliveries to prevent postpartum hemorrhage (PPH). Results indicated that administering carbetocin before placental delivery significantly reduced the incidence of PPH compared to after delivery (p=0.015) and resulted in a lower mean hemoglobin drop (p<0.001).
Key findings
- Incidence of PPH was significantly lower in the carbetocin-before group (p=0.015).
- Mean hemoglobin drop was significantly lower in the carbetocin-before group (p<0.001).
- Need for additional uterotonics was significantly higher in the carbetocin-after group (p<0.001).
- Manual placenta removal was more frequent in the carbetocin-before group (p=0.017).
Why it matters
Understanding the optimal timing for carbetocin administration can help clinicians reduce the risk of postpartum hemorrhage in low-risk vaginal deliveries, potentially improving maternal outcomes and minimizing the need for additional interventions.