Systematic review with network meta-analysis: efficacy and safety of minimally invasive interventions for symptomatic uterine fibroids.
Int J HyperthermiaJun 15, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Yue Li, Xing-Yi Wang, Ying Guo et al.
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In 30 seconds
This systematic review and network meta-analysis evaluated the efficacy and safety of minimally invasive interventions for symptomatic uterine fibroids in 2622 patients across 31 randomized controlled trials. High-intensity focused ultrasound (HIFU) demonstrated the highest efficacy for fibroid volume reduction (WMD = 10.31 vs UAE) and recurrence prevention (SUCRA = 70.1%).
Key findings
- HIFU ranked highest for fibroid volume reduction with a SUCRA of 96.7%.
- HIFU showed a WMD of 10.31 compared to UAE for fibroid volume reduction.
- MWA and HIFU had the lowest incidence of adverse events with SUCRA values of 78.8% and 69.7%, respectively.
- UAE ranked first for estradiol stability with a SUCRA of 77.0%.
Why it matters
Understanding the comparative efficacy and safety of minimally invasive treatments for uterine fibroids is crucial for clinicians to make informed, individualized treatment decisions, potentially improving patient outcomes and satisfaction.